About pancuronium bromide
Long-acting non-depolarizing neuromuscular blocker
Used for
- Relaxes skeletal muscles during general anesthesia and surgery
- Facilitates placement of a breathing tube and mechanical ventilation
Usual adult dose
Intravenous dosing is individualized by an anesthesia professional; commonly 0.04–0.1 mg/kg for intubation.
Usual dose in children
Used in children under anesthesia supervision; dosing is weight-based and individualized.
Common side effects
- Prolonged muscle weakness or paralysis
- Slow or fast heart rate
- Low blood pressure
- Allergic reactions, rarely severe
Important warnings
- Causes paralysis, including inability to breathe; requires ventilation and continuous monitoring.
- Only for use by trained clinicians where airway support and reversal treatment are available.
- Effects may last longer with kidney or liver impairment, older age, or certain medicines.
- Does not cause unconsciousness or relieve pain; anesthesia and pain control are also required.
Pregnancy
Use only when clinically necessary; evidence is limited, and anesthesia specialists should assess risks and benefits.
Breastfeeding
Information is limited; specialist assessment is appropriate after anesthesia. Pancuronium is expected to enter breast milk poorly.
Interactions
- Aminoglycoside antibiotics and magnesium may intensify or prolong paralysis.
- Inhaled anesthetics can increase or prolong its effects.
- Some medicines, including certain anticonvulsants, may alter its effect.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.