About maprotilin e
Tetracyclic antidepressant
Used for
- Major depressive disorder
Usual adult dose
Usually 25–75 mg daily initially; adjusted gradually. Typical maintenance is 75–150 mg daily, sometimes divided.
Common side effects
- Drowsiness, dizziness, fatigue
- Dry mouth, constipation, blurred vision
- Weight gain, increased appetite
- Low blood pressure, fast heartbeat
Important warnings
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can cause seizures and abnormal heart rhythms, particularly with high doses or overdose.
- Do not stop suddenly; withdrawal symptoms may occur.
- Use caution with glaucoma, urinary retention, heart disease, or seizure disorders.
Pregnancy
Use only when clearly needed; discuss risks and benefits with a healthcare professional. Late-pregnancy exposure may affect the newborn.
Breastfeeding
Maprotiline may pass into breast milk; infant effects are uncertain. Professional guidance is recommended.
Interactions
- MAO inhibitors: serious reactions; avoid concurrent use.
- Other medicines causing sedation increase drowsiness.
- Medicines affecting heart rhythm may increase abnormal rhythm risk.
- Some antidepressants and seizure-threshold-lowering medicines increase adverse-effect risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.