About probenecid
Uricosuric gout medicine
Used for
- Prevents gout attacks by lowering uric acid.
- Sometimes increases certain antibiotics’ blood levels.
Usual adult dose
Gout: usually 250 mg twice daily for one week, then 500 mg twice daily; may be increased gradually.
Usual dose in children
Not routinely used in children; specialist dosing depends on age and indication.
Common side effects
- Nausea, vomiting, or loss of appetite
- Headache or dizziness
- Gout flare when treatment begins
- Kidney stones
Important warnings
- Not for treating an acute gout attack.
- Drink adequate fluids; kidney stones can occur.
- Avoid with significant kidney impairment or uric acid kidney stones.
- Aspirin and some medicines can affect its action.
Pregnancy
Use only when clearly needed; pregnancy data are limited. A clinician should weigh potential benefits and risks.
Breastfeeding
Information is limited; discuss use with a healthcare professional, especially when nursing a newborn or premature infant.
Interactions
- Aspirin and other salicylates may reduce its uric-acid-lowering effect.
- Can raise levels of penicillin and some related antibiotics.
- May increase methotrexate levels and toxicity.
- May affect levels of sulfonylurea diabetes medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.