About dasatinib
Tyrosine kinase inhibitor
Used for
- Treats certain types of chronic myeloid leukaemia (CML).
- Treats Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph-positive ALL).
Usual adult dose
Usually 100 mg once daily for chronic-phase CML; 140 mg once daily for advanced CML or Ph-positive ALL.
Usual dose in children
Dose is based on body weight and condition; specialist-prescribed dosing is usually once daily.
Common side effects
- Low blood cell counts, increasing infection or bleeding risk
- Fluid retention, including fluid around the lungs
- Diarrhoea, nausea, vomiting, or abdominal pain
- Headache, tiredness, or rash
Important warnings
- Can cause severe low blood counts and bleeding.
- May cause fluid retention or heart and lung complications.
- Can affect heart rhythm and cause pulmonary arterial hypertension.
- Avoid grapefruit; monitoring and dose adjustment may be needed.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 30 days after the final dose.
Breastfeeding
Breastfeeding is not recommended during treatment and for two weeks after the final dose.
Interactions
- Strong CYP3A4 inhibitors or inducers can alter dasatinib levels.
- Acid-reducing medicines, including proton-pump inhibitors, can reduce absorption.
- Avoid medicines that prolong the QT interval when possible.
- Blood thinners and medicines affecting platelets may increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.