About diluted isosorbide dinitrate
Nitrate vasodilator
Used for
- Prevention of angina (heart-related chest pain)
- Treatment of heart failure, usually with other medicines
Usual adult dose
Angina: usually 5–20 mg by mouth two or three times daily; dosing depends on formulation. Heart failure doses are individualized.
Common side effects
- Headache
- Dizziness or lightheadedness
- Flushing
- Low blood pressure
Important warnings
- Can cause fainting, especially when standing or with alcohol.
- Do not combine with sildenafil, tadalafil, vardenafil, or riociguat; blood pressure may fall dangerously.
- Regular dosing may cause tolerance; a daily nitrate-free interval may be needed.
- Not for immediate relief of a sudden angina attack.
Pregnancy
Use only when clearly needed; safety information in pregnancy is limited.
Breastfeeding
Information is limited; use requires consideration of benefits and potential risks.
Interactions
- Sildenafil, tadalafil, vardenafil, or riociguat: severe low blood pressure risk.
- Blood-pressure medicines and alcohol: increased dizziness or low blood pressure.
- Other nitrates: increased effects and adverse effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.