About lomitapide mesylate
Microsomal triglyceride transfer protein inhibitor
Used for
- Lowers LDL cholesterol in adults with homozygous familial hypercholesterolaemia, alongside other lipid-lowering treatments.
Usual adult dose
Start at 5 mg once daily; increase gradually under specialist supervision to a maximum of 60 mg daily.
Common side effects
- Diarrhoea, nausea, vomiting, and abdominal pain
- Raised liver enzymes and fatty liver
- Indigestion and reduced appetite
Important warnings
- For specialist use; continue a low-fat diet and other prescribed cholesterol treatments.
- Requires regular liver tests; serious liver injury can occur.
- Avoid in moderate or severe liver impairment.
- Can cause fetal harm; effective contraception is required during treatment.
Pregnancy
Do not use during pregnancy; it may harm an unborn baby.
Breastfeeding
Breastfeeding is not recommended during treatment.
Interactions
- Strong CYP3A4 inhibitors, including some antibiotics and antifungals, are contraindicated.
- May interact with statins, increasing muscle injury risk.
- May reduce absorption of fat-soluble vitamins and essential fatty acids.
- Warfarin effects may change; monitoring is needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.