About esomeprazole sodium
Proton pump inhibitor
Used for
- Short-term treatment of severe reflux when oral treatment is not possible
- Prevention of rebleeding after endoscopic treatment of bleeding stomach or duodenal ulcers
Usual adult dose
Usually 20–40 mg once daily for reflux; after ulcer bleeding, 80 mg infusion followed by 8 mg/hour for 72 hours.
Usual dose in children
For reflux when oral treatment is not possible: ages 1–11 years, 10 or 20 mg once daily; ages 12–17 years, 20 or 40 mg once daily.
Common side effects
- Headache
- Abdominal pain, nausea, or diarrhea
- Injection-site reactions
- Low magnesium with prolonged use
Important warnings
- Use IV treatment only when oral therapy is unsuitable; switch to oral treatment when possible.
- Seek urgent care for possible severe allergic reaction or severe skin rash.
- Long-term use may increase fracture, vitamin B12 deficiency, and certain infection risks.
- Dose adjustment may be needed in severe liver disease.
Pregnancy
Human safety information is limited; use only when a clinician considers treatment necessary.
Breastfeeding
Information is limited; discuss use with a healthcare professional.
Interactions
- May reduce absorption of medicines needing stomach acid, such as some antifungals.
- Can interact with clopidogrel, warfarin, methotrexate, and digoxin.
- May affect medicines processed by liver enzymes, including diazepam and phenytoin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.