About alogliptin benzoate + pioglitazone hcl
DPP-4 inhibitor and thiazolidinedione
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually one tablet once daily; dosing depends on prior medicines and kidney function.
Common side effects
- Cold-like symptoms or sore throat
- Headache
- Swelling or rapid weight gain
- Low blood sugar, especially with insulin or sulfonylureas
Important warnings
- May cause or worsen heart failure; avoid starting in severe heart failure.
- Can cause fluid retention, fractures, or liver problems.
- Seek urgent care for severe, persistent abdominal pain or allergic swelling.
- Not for type 1 diabetes or diabetic ketoacidosis.
Pregnancy
Not recommended for diabetes treatment during pregnancy; insulin is generally preferred. Discuss treatment with a clinician.
Breastfeeding
There is limited information about use while breastfeeding; discuss options with a clinician.
Interactions
- Insulin or sulfonylureas can increase low blood sugar risk.
- Strong CYP2C8 inhibitors, such as gemfibrozil, can increase pioglitazone exposure.
- Strong CYP2C8 inducers, such as rifampin, can reduce pioglitazone exposure.
- Pioglitazone may affect medicines metabolized by CYP2C8, including some diabetes drugs.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.