About daclatasvir
Hepatitis C NS5A inhibitor
Used for
- Chronic hepatitis C, combined with other antiviral medicines
Usual adult dose
Once daily with other hepatitis C antivirals, usually for 12–24 weeks. Dose adjustments may be needed for interacting medicines.
Common side effects
- Headache
- Tiredness
- Nausea
- Diarrhea
Important warnings
- Not effective alone; always combined with other hepatitis C antivirals
- Hepatitis B may reactivate; screening is required before treatment
- Amiodarone with sofosbuvir combinations can cause dangerously slow heartbeat
- Treatment selection depends on hepatitis C type and liver disease
Pregnancy
Pregnancy safety is not established. Combinations containing ribavirin are contraindicated during pregnancy because ribavirin causes birth defects.
Breastfeeding
Whether daclatasvir passes into human breast milk is unknown. Breastfeeding safety has not been established.
Interactions
- Rifampicin, carbamazepine, phenytoin, and St John's wort reduce effectiveness
- Clarithromycin and certain HIV medicines may require dose adjustment
- Amiodarone with sofosbuvir increases risk of dangerously slow heartbeat
- May increase digoxin and some statin levels
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.