About hydrocortisone
Corticosteroid (glucocorticoid)
Used for
- Hormone replacement for adrenal insufficiency
- Treatment of severe inflammation or allergic conditions
Usual adult dose
Adrenal replacement is usually 15–25 mg daily in divided doses; other conditions require individualized dosing.
Usual dose in children
For adrenal replacement, usually 8–10 mg/m² daily in three divided doses; specialist adjustment is required.
Common side effects
- Indigestion or increased appetite
- Mood changes or difficulty sleeping
- Raised blood sugar
- Long-term use may weaken bones and increase infection risk
Important warnings
- Do not stop long-term treatment suddenly.
- Illness, injury, or surgery may require temporary dose increases.
- Long-term use can suppress natural steroid production.
- Use cautiously with infections, diabetes, or stomach ulcers.
Pregnancy
May be used when needed; the prescriber may adjust treatment and monitor during pregnancy.
Breastfeeding
Generally compatible at usual replacement doses; higher or prolonged doses may require monitoring.
Interactions
- Rifampicin, carbamazepine, and phenytoin may reduce hydrocortisone effects.
- Ritonavir and azole antifungals may increase effects.
- NSAIDs may increase stomach ulcer or bleeding risk.
- Warfarin effects may change; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.