About pioglitazo ne
Thiazolidinedione antidiabetic
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually 15 or 30 mg once daily; may increase to 45 mg once daily.
Common side effects
- Fluid retention, swelling, and weight gain
- Heart failure or worsening heart failure
- Low blood sugar when combined with some diabetes medicines
- Fractures; possible macular edema
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Can cause or worsen heart failure; avoid in severe heart failure.
- Report blood in urine or painful urination; bladder cancer risk is uncertain.
- May restore ovulation and increase pregnancy risk in some people.
Pregnancy
Safety is not established; use during pregnancy only when clearly needed, as directed by a clinician.
Breastfeeding
Unknown whether it passes into human milk; discuss use with a clinician.
Interactions
- Insulin and sulfonylureas can increase low blood sugar and fluid retention.
- Gemfibrozil can increase pioglitazone exposure.
- Rifampin can reduce pioglitazone exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.