About mitotane
Adrenocortical cytotoxic medicine
Used for
- Treats adrenocortical carcinoma, usually under specialist supervision.
Usual adult dose
Usually starts at 2–6 g daily in divided doses; specialists adjust to blood levels and tolerance.
Common side effects
- Nausea, vomiting, diarrhoea, or loss of appetite
- Dizziness, sleepiness, or confusion
- Rash
- Adrenal insufficiency
Important warnings
- Requires specialist monitoring of blood mitotane levels and adrenal function.
- Can cause severe adrenal insufficiency; steroid replacement may be needed.
- May cause drowsiness or dizziness; avoid driving if affected.
- Can remain in the body for months after stopping.
Pregnancy
Can harm an unborn baby. Effective contraception is needed during treatment and for a prolonged period afterward.
Breastfeeding
Breastfeeding is not recommended during treatment or for a prolonged period after stopping.
Interactions
- Can reduce the effects of hormonal contraceptives; use non-hormonal contraception.
- May alter levels or effects of warfarin and other medicines.
- Steroid medicines may require dose adjustment.
- Avoid medicines that increase drowsiness unless supervised.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.