About ceritinib
ALK tyrosine kinase inhibitor
Used for
- Treats ALK-positive advanced non-small cell lung cancer.
Usual adult dose
450 mg by mouth once daily with food; continue until disease worsens or side effects become unacceptable.
Common side effects
- Diarrhea, nausea, vomiting, and abdominal pain
- Liver enzyme increases
- Fatigue and reduced appetite
- High blood sugar and slow heart rate
Important warnings
- Can cause severe liver problems; monitoring is required.
- Can cause serious stomach or intestinal problems, including inflammation or perforation.
- May prolong the heart’s electrical activity or slow the heart rate.
- Can cause severe lung inflammation; report new or worsening breathing problems.
Pregnancy
May harm an unborn baby. Effective contraception is advised during treatment and for 6 months afterward.
Breastfeeding
Do not breastfeed during treatment or for 2 weeks after the final dose.
Interactions
- Avoid strong CYP3A inhibitors and inducers; they can change ceritinib levels.
- Avoid medicines that prolong the QT interval when possible.
- Avoid grapefruit and grapefruit juice.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.