About tacrolimu s
Calcineurin inhibitor immunosuppressant
Used for
- Prevents organ rejection after kidney, liver, or heart transplantation.
Usual adult dose
Individualized and adjusted using blood tests; usually taken once daily.
Usual dose in children
Individualized by transplant specialists; dosing depends on weight, organ transplanted, and blood test results.
Common side effects
- Tremor, headache, or trouble sleeping
- High blood pressure or blood sugar
- Kidney problems
- Increased risk of infections
Important warnings
- Take consistently at the same time, as directed; do not switch formulations without specialist guidance.
- Requires regular blood tests and monitoring of kidney function and blood pressure.
- Avoid grapefruit and grapefruit juice; they can raise tacrolimus levels.
- Seek medical attention for signs of serious infection or unusual skin changes.
Pregnancy
May be used when necessary, but requires specialist assessment and close monitoring; discuss pregnancy plans with the transplant team.
Breastfeeding
Tacrolimus enters breast milk; breastfeeding decisions require specialist assessment and monitoring.
Interactions
- Strongly affected by medicines that alter CYP3A enzymes, including some antifungals, antibiotics, and seizure medicines.
- Grapefruit can increase tacrolimus levels.
- Other medicines that harm the kidneys may increase kidney injury risk.
- Live vaccines may be less effective or unsafe during treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.