About amoxicillin + clavulanate
Penicillin antibiotic with beta-lactamase inhibitor
Used for
- Treats susceptible bacterial infections, including respiratory, urinary, skin, and abdominal infections.
- Used for some serious infections requiring injection into a vein.
Usual adult dose
IV dosing varies by infection and kidney function; a common regimen is 1.2 g every 8 hours.
Usual dose in children
IV dosing is based on weight and infection; commonly 25–30 mg/kg every 8 hours, expressed as combined ingredients.
Common side effects
- Diarrhea, nausea, or vomiting
- Rash or allergic reactions
- Injection-site discomfort
- Rarely, liver inflammation or severe skin reactions
Important warnings
- Do not use with serious allergy to penicillins or related antibiotics.
- Previous jaundice or liver problems caused by this medicine are a contraindication.
- Kidney impairment may require dose adjustment.
- Use only for bacterial infections; unnecessary use promotes antibiotic resistance.
Pregnancy
Can be used when clinically indicated; available evidence has not shown a clear increase in birth defects.
Breastfeeding
Generally compatible; monitor for infant diarrhea, rash, or thrush.
Interactions
- Warfarin and similar anticoagulants: altered clotting results may occur.
- Allopurinol: increased risk of skin rash.
- Probenecid: can increase amoxicillin levels.
- Methotrexate: may increase methotrexate exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.