About ripretinib
Tyrosine kinase inhibitor
Used for
- Treatment of advanced gastrointestinal stromal tumors (GIST) after prior treatments.
Usual adult dose
150 mg by mouth once daily; a specialist may increase to 150 mg twice daily if disease worsens.
Common side effects
- Hair thinning or loss
- Tiredness
- Nausea or constipation
- Muscle or joint pain
Important warnings
- Can cause skin cancers; regular skin checks are recommended.
- May cause high blood pressure or heart problems.
- Can impair wound healing; surgery may require a treatment break.
- May harm an unborn baby; effective contraception is needed during treatment.
Pregnancy
May cause fetal harm. Avoid during pregnancy; use effective contraception during treatment and for at least one week after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment or for one week after the last dose.
Interactions
- Strong CYP3A inducers can lower ripretinib levels and reduce effectiveness.
- Strong CYP3A inhibitors can raise ripretinib levels and increase side effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.