About bedaquiline fumarate
Diary lquinoline antimycobacterial
Used for
- Used with other medicines to treat multidrug-resistant pulmonary tuberculosis in adults and eligible children.
Usual adult dose
400 mg once daily for 2 weeks, then 200 mg three times weekly for 22 weeks, with other tuberculosis medicines.
Usual dose in children
For children aged 5 years or older and weighing at least 15 kg: weight-based dosing, usually 24 weeks, with other tuberculosis medicines.
Common side effects
- Nausea, joint pain, headache, or dizziness
- Abnormal liver tests
- Heart rhythm changes, including QT prolongation
Important warnings
- Can cause serious, potentially fatal heart rhythm problems.
- Liver injury is possible; monitoring is needed during treatment.
- Must be used with other tuberculosis medicines under specialist supervision.
- Treatment duration and dosing require careful adherence.
Pregnancy
Human pregnancy data are limited. Use requires specialist assessment of potential benefits and risks.
Breastfeeding
It is unknown whether bedaquiline passes into breast milk; a clinician should weigh treatment benefits and potential risks.
Interactions
- Other medicines that prolong the QT interval may increase heart rhythm risk.
- Rifampin and other strong enzyme-inducing medicines can reduce bedaquiline levels.
- Some antifungal and HIV medicines can alter bedaquiline levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.