About human prothrombin complex
Four-factor prothrombin complex concentrate
Used for
- Rapidly reverses vitamin K antagonist effects, such as warfarin, when urgent reversal is needed.
- Treats bleeding or helps prevent bleeding before urgent surgery in people taking vitamin K antagonists.
Usual adult dose
Given by intravenous infusion; dose depends on body weight and INR, typically 25–50 IU/kg under the product protocol.
Usual dose in children
Use in children is not routinely established; specialist-directed dosing depends on weight and clinical circumstances.
Common side effects
- Blood clots, including stroke, heart attack, or deep-vein thrombosis
- Allergic reactions, including severe hypersensitivity
- Headache, nausea, or vomiting
- Rarely, low blood pressure or fever
Important warnings
- Use only when rapid clotting-factor replacement is needed; clotting complications can be serious.
- Contains heparin; avoid in heparin-induced thrombocytopenia.
- Monitor clotting tests and clinical response during treatment.
- May contain trace proteins; severe allergy to product components is possible.
Pregnancy
Use only if clearly necessary; pregnancy safety information is limited, and clotting risks require specialist assessment.
Breastfeeding
There is limited information; use requires clinician assessment of benefits and risks.
Interactions
- Vitamin K antagonists, including warfarin, are reversed by treatment.
- Other clotting-factor products or medicines that increase clotting may raise thrombosis risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.