About lorlatinib
ALK and ROS1 tyrosine kinase inhibitor
Used for
- Treats ALK-positive non-small cell lung cancer in adults.
Usual adult dose
100 mg by mouth once daily, with or without food; dose adjustments may be needed.
Common side effects
- Swelling, numbness, or tingling
- High cholesterol or triglycerides
- Weight gain
- Changes in thinking, mood, speech, or vision
Important warnings
- Can cause serious changes in mood, thinking, speech, or sleep.
- May cause high cholesterol, high triglycerides, or heart rhythm changes.
- Can cause lung inflammation or liver problems.
- Avoid grapefruit and St. John’s wort; regular blood tests are needed.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 6 months after the final dose.
Breastfeeding
Do not breastfeed during treatment and for 7 days after the final dose.
Interactions
- Strong CYP3A inducers can cause severe liver injury.
- Strong CYP3A inhibitors can raise lorlatinib levels.
- Lorlatinib can reduce the effectiveness of hormonal contraceptives.
- It can affect levels of many medicines, including some heart and cholesterol drugs.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.