About hydroxyzine hydrochloride
First-generation antihistamine
Used for
- Short-term relief of itching from allergic conditions
- Relief of anxiety and tension
- Sedation before or after medical procedures
Usual adult dose
Itching: 25 mg three or four times daily. Anxiety: 50–100 mg up to four times daily; doses vary by country and indication.
Usual dose in children
Itching: 0.5–1 mg/kg per dose, up to four times daily; maximum 2 mg/kg daily for children weighing 40 kg or less.
Common side effects
- Drowsiness and reduced alertness
- Dry mouth
- Dizziness
- Headache
Important warnings
- Can impair driving and coordination; alcohol increases sedation.
- May prolong the heart rhythm QT interval, rarely causing dangerous arrhythmias.
- Use the lowest effective dose for the shortest time; older adults are more sensitive.
- Avoid or seek medical guidance with heart rhythm problems, glaucoma, or difficulty urinating.
Pregnancy
Generally avoid, especially in early pregnancy; use only if a clinician determines it is necessary.
Breastfeeding
Not recommended; it may cause infant drowsiness or reduce milk supply.
Interactions
- Alcohol, opioids, sleeping medicines, and other sedatives increase drowsiness.
- Medicines that prolong QT, including some antibiotics and antipsychotics, increase heart rhythm risk.
- Other anticholinergic medicines can worsen dry mouth, constipation, or urinary problems.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.