About ondansetr on hydrochlo
5-HT3 serotonin receptor antagonist
Used for
- Prevention and treatment of nausea and vomiting from chemotherapy or radiotherapy
- Prevention and treatment of nausea and vomiting after surgery
Usual adult dose
Usually 4 mg by injection for postoperative nausea; chemotherapy doses vary by regimen, commonly 8 mg before treatment.
Usual dose in children
For chemotherapy, usually 0.15 mg/kg intravenously per dose, up to 8 mg; dosing depends on age and regimen.
Common side effects
- Headache
- Constipation
- Flushing
- Injection-site reactions
Important warnings
- Can prolong the heart’s QT interval and rarely cause serious rhythm problems.
- Seek urgent care for allergic reactions or signs of serotonin syndrome.
- Use caution with severe liver impairment; total daily dose may need limiting.
- May mask symptoms of bowel obstruction.
Pregnancy
Use only when clinically needed; safety information is limited, especially early in pregnancy.
Breastfeeding
Information is limited; discuss use with a healthcare professional.
Interactions
- Apomorphine: risk of profound low blood pressure and loss of consciousness.
- Other QT-prolonging medicines may increase abnormal heart rhythm risk.
- Serotonergic medicines may increase serotonin syndrome risk.
- Some enzyme-inducing medicines can reduce ondansetron levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.