About diloxanide furoate + metronidazole
Antiprotozoal combination
Used for
- Treatment of intestinal amoebiasis, including amoebic dysentery.
- Diloxanide treats amoebae in the intestine; metronidazole treats invasive infection.
Usual adult dose
Common regimens use diloxanide furoate 500 mg plus metronidazole 400–800 mg, three times daily for 5–10 days; combination-product schedules vary.
Usual dose in children
Dosing depends on age and weight; specialist guidance is needed for this combination.
Common side effects
- Nausea, vomiting, or abdominal discomfort
- Metallic taste or reduced appetite
- Headache or dizziness
- Dark urine
Important warnings
- Avoid alcohol during metronidazole treatment and for at least 48 hours afterward.
- Metronidazole can cause numbness, tingling, or other nerve symptoms, especially with prolonged use.
- Use caution with liver disease or a history of blood disorders.
- Amoebic liver or other extraintestinal disease requires different treatment.
Pregnancy
Use only when clearly needed, particularly during the first trimester; clinical assessment is required.
Breastfeeding
Metronidazole passes into breast milk; treatment decisions depend on dose and duration.
Interactions
- Warfarin and similar anticoagulants: increased bleeding risk
- Disulfiram: possible serious mental or behavioral reactions
- Lithium: blood levels may rise
- Alcohol: can cause an unpleasant reaction during treatment and shortly afterward
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.