About aprotinin
Serine protease inhibitor
Used for
- Reduces bleeding during selected high-risk cardiac surgery involving cardiopulmonary bypass.
Usual adult dose
Specialist-directed intravenous dosing during surgery; regimens use a loading dose, infusion, and pump prime dose.
Common side effects
- Allergic reactions, including severe anaphylaxis
- Kidney injury
- Blood clots
- Low blood pressure
Important warnings
- Restricted use because of serious kidney, allergic, and clotting risks.
- Prior aprotinin exposure increases the risk of severe allergic reactions.
- Use only in cardiac surgery settings with specialist monitoring.
- Avoid in patients with known aprotinin allergy.
Pregnancy
Use only when essential; safety in pregnancy is not established.
Breastfeeding
Unknown whether aprotinin passes into breast milk; use only after specialist assessment.
Interactions
- May increase clotting when combined with antifibrinolytic medicines such as tranexamic acid.
- May alter coagulation test results during cardiac surgery.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.