About pancuronium bromide
Non-depolarizing neuromuscular blocking agent
Used for
- Relaxes skeletal muscles during general anesthesia and surgery
- Helps facilitate endotracheal intubation and mechanical ventilation
Usual adult dose
Given intravenously by an anesthetist; an initial dose is commonly 0.04–0.1 mg/kg, adjusted to muscle-response monitoring.
Usual dose in children
Given intravenously by an anesthetist; dosing is weight-based and varies with age and procedure.
Common side effects
- Prolonged muscle weakness or paralysis
- Fast heart rate
- Low blood pressure
- Increased saliva or airway secretions
Important warnings
- Causes paralysis, including inability to breathe; ventilation and resuscitation equipment are essential.
- Use only by trained clinicians with continuous monitoring.
- Does not provide unconsciousness or pain relief; anesthesia is required.
- Effects may be prolonged by kidney or liver impairment and some medicines.
Pregnancy
Use only when clearly needed during anesthesia; newborn muscle weakness or breathing difficulty may occur.
Breastfeeding
Safety information is limited; clinical decisions should consider the need for treatment and infant monitoring.
Interactions
- Anesthetic gases and some antibiotics can intensify or prolong paralysis.
- Other neuromuscular blockers can intensify its effects.
- Some seizure medicines may reduce its effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.