About tacrolimus monohydrate eq to tacrolimus
Calcineurin inhibitor immunosuppressant
Used for
- Prevents organ rejection after kidney, liver, or heart transplantation.
- Treats rejection of transplanted organs.
Usual adult dose
Varies by organ transplant, blood levels, and other medicines; specialists individualize dosing.
Usual dose in children
Used in children after transplantation; specialists calculate and adjust dosing by weight and blood levels.
Common side effects
- Tremor, headache, or sleep problems
- High blood pressure
- Kidney problems
- Increased blood sugar and infection risk
Important warnings
- Requires regular blood tests and careful dose monitoring.
- Can cause serious kidney or nervous system toxicity.
- Increases risk of serious infections and some cancers.
- Do not switch brands or formulations without transplant-team oversight.
Pregnancy
May be used when necessary, but can increase risks such as premature birth; specialist monitoring is important.
Breastfeeding
Tacrolimus enters breast milk; discuss potential risks and monitoring with a clinician.
Interactions
- Grapefruit can raise tacrolimus levels.
- Some antibiotics and antifungals can raise levels.
- Rifampin and certain seizure medicines can lower levels.
- Avoid live vaccines unless the transplant team approves.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.