About ceritinib
ALK inhibitor anticancer medicine
Used for
- Treats ALK-positive advanced non-small-cell lung cancer.
Usual adult dose
450 mg by mouth once daily with food; continue until disease progression or unacceptable side effects.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Fatigue and reduced appetite
- Liver enzyme abnormalities
- Raised blood sugar or slowed heart rate
Important warnings
- Can cause serious liver injury; monitoring is required.
- May cause pancreatitis, lung inflammation, or heart rhythm changes.
- Can cause severe diarrhea and dehydration.
- Avoid grapefruit and grapefruit juice.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for at least six months afterward.
Breastfeeding
Breastfeeding is not recommended during treatment or for two weeks after the final dose.
Interactions
- Strong CYP3A inhibitors can increase ceritinib levels.
- Strong CYP3A inducers can reduce ceritinib levels.
- Ceritinib can affect medicines metabolized by CYP3A or CYP2C9.
- Medicines that prolong the QT interval may increase heart rhythm risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.