About ondansetr on hudrochlo
Serotonin 5-HT3 receptor antagonist
Used for
- Prevention and treatment of nausea and vomiting from chemotherapy
- Prevention and treatment of nausea and vomiting after surgery
Usual adult dose
Adults: commonly 4 mg intravenously for surgery-related nausea; chemotherapy doses vary by regimen.
Usual dose in children
Children: commonly 0.1 mg/kg intravenously before surgery, maximum 4 mg; chemotherapy dosing varies by regimen.
Common side effects
- Headache
- Constipation or diarrhea
- Dizziness
- Injection-site reactions
Important warnings
- May prolong the heart rhythm (QT interval), especially with certain conditions or medicines.
- Rarely causes severe allergic reactions or serotonin syndrome.
- Use caution with bowel obstruction, as it may mask worsening symptoms.
- Dose adjustment may be needed in severe liver disease.
Pregnancy
May be used when clinically needed; discuss potential benefits and risks with a healthcare professional.
Breastfeeding
Information is limited; use requires consideration of the potential benefits and risks.
Interactions
- Apomorphine: combination is contraindicated because of severe low blood pressure and loss of consciousness risk.
- Other medicines that prolong the QT interval can increase abnormal heart rhythm risk.
- Serotonergic medicines may increase the risk of serotonin syndrome.
- Phenytoin, carbamazepine, and rifampicin may reduce ondansetron levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.