About linaclotide
Guanylate cyclase-C agonist
Used for
- Irritable bowel syndrome with constipation in adults
- Chronic idiopathic constipation in adults
Usual adult dose
IBS with constipation: 290 micrograms by mouth once daily. Chronic idiopathic constipation: 145 micrograms once daily; 72 micrograms may be used.
Common side effects
- Diarrhea
- Abdominal pain
- Gas
- Abdominal bloating
Important warnings
- Can cause severe diarrhea and dehydration; stop and seek medical care if severe.
- Do not use in children under 2 years; risk of serious dehydration.
- Not recommended for children aged 2–17 years.
- Take on an empty stomach, at least 30 minutes before a meal.
Pregnancy
Human pregnancy data are limited. Animal studies found no clear harm at doses above usual human exposure.
Breastfeeding
It is unknown whether linaclotide passes into breast milk; systemic absorption is minimal.
Interactions
- Few interactions are expected because very little linaclotide is absorbed into the bloodstream.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.