About saxagliptin
DPP-4 inhibitor for type 2 diabetes
Used for
- Helps control blood sugar in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually 2.5 or 5 mg by mouth once daily; dose may be lower with kidney problems or certain medicines.
Common side effects
- Upper respiratory infections
- Headache
- Urinary tract infections
- Low blood sugar, especially with insulin or sulfonylureas
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Can cause or worsen heart failure; seek prompt care for breathlessness or swelling.
- Rarely causes severe joint pain or serious allergic reactions.
- Pancreatitis has been reported; stop and seek care for severe persistent abdominal pain.
Pregnancy
Pregnancy data are limited; use only when a clinician considers it necessary. Insulin is generally preferred for diabetes during pregnancy.
Breastfeeding
It is unknown whether saxagliptin passes into breast milk; discuss suitable treatment with a clinician.
Interactions
- Strong CYP3A4/5 inhibitors, such as ketoconazole, can increase saxagliptin levels.
- Strong CYP3A4/5 inducers, such as rifampin, may reduce its effect.
- Insulin or sulfonylureas increase low-blood-sugar risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.