About indometacin
Nonsteroidal anti-inflammatory drug (NSAID)
Used for
- Relief of pain and inflammation in arthritis
- Treatment of acute gouty arthritis
- Relief of pain from shoulder bursitis or tendon inflammation
Usual adult dose
Usually 50 mg rectally two or three times daily; dosing depends on the condition.
Common side effects
- Nausea, indigestion, or abdominal pain
- Dizziness or headache
- Rectal irritation or discomfort
- Fluid retention or increased blood pressure
Important warnings
- Can cause stomach ulcers, bleeding, or perforation.
- May increase risk of heart attack or stroke.
- Can worsen kidney or heart problems.
- Avoid during late pregnancy; use only when prescribed.
Pregnancy
Avoid from 20 weeks unless specifically prescribed; avoid from 30 weeks because of fetal risks.
Breastfeeding
Small amounts may enter milk; short-term use is generally considered compatible, but seek clinician guidance.
Interactions
- Blood thinners and antiplatelet medicines increase bleeding risk.
- Other NSAIDs or aspirin increase stomach and kidney risks.
- ACE inhibitors, ARBs, and diuretics may increase kidney risks.
- Lithium or methotrexate levels may rise.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.