About aprepitant
Neurokinin-1 receptor antagonist antiemetic
Used for
- Prevents nausea and vomiting caused by chemotherapy
- Prevents nausea and vomiting after surgery
Usual adult dose
Chemotherapy: 125 mg by mouth on day 1, then 80 mg daily on days 2 and 3, with other antiemetics. Surgery: 40 mg once before anesthesia.
Usual dose in children
For chemotherapy, dosing depends on age, weight, and formulation; capsules are generally for children aged 12 years or older, using prescribed weight-based dosing.
Common side effects
- Tiredness or weakness
- Hiccups
- Indigestion or constipation
- Headache
Important warnings
- Can reduce hormonal contraceptive effectiveness during treatment and for 28 days afterward.
- May cause serious allergic reactions, though uncommon.
- Dose adjustments may be needed with severe liver disease.
- Capsules are not suitable for every child; pediatric formulations and dosing differ.
Pregnancy
Human pregnancy information is limited; use only when clearly needed and under medical supervision.
Breastfeeding
It is not known whether aprepitant passes into human milk; discuss use with a healthcare professional.
Interactions
- Can reduce hormonal contraceptive effectiveness.
- Interactions with warfarin may alter INR; monitoring is recommended.
- Strong CYP3A4 inhibitors or inducers can substantially change aprepitant levels.
- May alter levels of drugs such as dexamethasone, midazolam, and some chemotherapy medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.