About amlodipine besilate + atorvastatin calcium
Calcium-channel blocker and statin
Used for
- Treats high blood pressure or angina in people who also need cholesterol reduction.
- Lowers LDL cholesterol and reduces cardiovascular risk in suitable patients.
Usual adult dose
Usually one tablet once daily; doses are individualized for blood pressure and cholesterol goals.
Usual dose in children
Not used as this combination in children.
Common side effects
- Swollen ankles, headache, flushing, dizziness
- Muscle aches or weakness
- Indigestion, nausea, or diarrhea
- Raised liver enzymes
Important warnings
- Seek urgent care for severe muscle pain or weakness, especially with fever or dark urine.
- Liver problems can occur; monitoring may be needed.
- May cause dizziness or low blood pressure, particularly when starting treatment.
- Avoid grapefruit products; they can increase atorvastatin exposure.
Pregnancy
Do not use during pregnancy; atorvastatin can harm the developing baby.
Breastfeeding
Avoid during breastfeeding because atorvastatin may pass into breast milk.
Interactions
- Strong CYP3A4 inhibitors, such as clarithromycin, can raise drug levels.
- Some HIV or hepatitis C medicines can increase atorvastatin-related muscle injury risk.
- Other cholesterol medicines, including gemfibrozil, increase muscle injury risk.
- Rifampicin, St John’s wort, and grapefruit can alter drug levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.