About edrophonium
Short-acting acetylcholinesterase inhibitor
Used for
- Historically used to help diagnose myasthenia gravis.
- Used to reverse certain muscle-relaxing medicines after surgery.
Usual adult dose
Diagnostic testing: 2 mg IV, then 8 mg if needed after 30–60 seconds. Reversal: typically 0.5–1 mg/kg IV, guided by monitoring.
Usual dose in children
Reversal: typically 0.5–1 mg/kg IV, guided by monitoring; specialist use only.
Common side effects
- Slow heartbeat or abnormal heart rhythm
- Increased saliva, sweating, or tears
- Nausea, vomiting, or abdominal cramps
- Muscle twitching or weakness
Important warnings
- Can cause severe slow heartbeat, breathing problems, or cholinergic crisis.
- Use only with monitoring and resuscitation equipment available.
- Avoid or use caution with asthma, heart rhythm problems, or intestinal or urinary blockage.
- Availability and approved uses vary by country.
Pregnancy
Use only when clearly needed; pregnancy safety information is limited.
Breastfeeding
Breastfeeding safety information is limited; seek specialist guidance.
Interactions
- Other acetylcholinesterase inhibitors may increase effects and toxicity.
- Antimuscarinic medicines, such as atropine, can oppose some effects.
- May interact with medicines affecting heart rate or neuromuscular function.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.