About hydroflumethiazide + spironolactone
Thiazide diuretic and aldosterone antagonist
Used for
- High blood pressure
- Fluid retention associated with heart, liver, or kidney conditions
Usual adult dose
Dosing varies by condition; combination products are commonly taken once or twice daily as prescribed.
Common side effects
- Increased urination
- Dizziness or low blood pressure
- High potassium
- Breast tenderness or enlargement
Important warnings
- May cause dangerously high potassium, especially with kidney problems.
- Can disturb sodium and other electrolyte levels; blood tests may be needed.
- Avoid potassium supplements and salt substitutes containing potassium unless prescribed.
- May cause dehydration or worsen kidney function.
Pregnancy
Generally avoid during pregnancy unless a clinician determines benefits outweigh risks; spironolactone may affect fetal development.
Breastfeeding
Use only with professional guidance; spironolactone enters breast milk in small amounts, and information on hydroflumethiazide is limited.
Interactions
- ACE inhibitors, ARBs, and potassium-sparing medicines can raise potassium.
- Potassium supplements and potassium-containing salt substitutes increase high-potassium risk.
- Lithium levels may rise.
- NSAIDs can reduce diuretic effects and affect kidney function.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.