About tacrolimus
Calcineurin inhibitor immunosuppressant
Used for
- Prevents organ rejection after kidney, liver, or heart transplantation.
Usual adult dose
Individualized by transplant type, blood levels, and response; taken once daily. Doses vary widely.
Usual dose in children
Specialist-set and adjusted using blood levels; dosing varies by transplant and child.
Common side effects
- Tremor, headache, or trouble sleeping
- High blood pressure or raised blood sugar
- Kidney problems
- Increased risk of infections
Important warnings
- Take consistently once daily; do not switch brands or formulations without transplant-team guidance.
- Blood tests are needed to monitor tacrolimus levels, kidney function, and other effects.
- Do not stop suddenly; rejection can occur.
- Avoid grapefruit and grapefruit juice; infection risk and some cancers are increased.
Pregnancy
May be used when needed after specialist assessment; it can increase risks such as high blood pressure and diabetes during pregnancy.
Breastfeeding
Tacrolimus enters breast milk. Breastfeeding decisions require discussion with the transplant specialist and monitoring of the infant.
Interactions
- Strong CYP3A inhibitors, including clarithromycin and azole antifungals, can raise levels.
- Rifampicin and some seizure medicines can lower levels.
- Other kidney-toxic medicines can increase kidney injury risk.
- Grapefruit can raise tacrolimus levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.