About acenocoumarol
Vitamin K antagonist anticoagulant
Used for
- Prevention and treatment of blood clots, including deep vein thrombosis and pulmonary embolism
- Prevention of clots in people with certain heart conditions or artificial heart valves
Usual adult dose
Adjusted individually using regular INR blood tests; dosing varies by patient and clinical target.
Usual dose in children
Specialist-directed, adjusted individually using INR tests; dosing depends on age, weight, and indication.
Common side effects
- Bleeding, including bruising, nosebleeds, or blood in urine
- Nausea or vomiting
- Rash or itching
- Rarely, painful skin damage or liver problems
Important warnings
- Can cause serious or fatal bleeding; seek urgent care for severe bleeding or head injury.
- Requires frequent INR monitoring; dose changes should follow clinician instructions.
- Many medicines, supplements, alcohol, and changes in diet can alter its effect.
- Generally avoided in pregnancy because it can harm the fetus; specialist exceptions may apply.
Pregnancy
Usually contraindicated because of fetal harm and bleeding risk; some patients with mechanical valves need specialist-managed alternatives or exceptions.
Breastfeeding
Generally considered compatible with breastfeeding; clinical monitoring is appropriate, especially for newborn or premature infants.
Interactions
- Interactions include antibiotics, antifungals, pain relievers, and many heart medicines.
- Vitamin K supplements and major changes in leafy-green intake can alter anticoagulation.
- St John's wort and some seizure medicines may reduce its effect.
- Alcohol can change its effect and increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.