About entacapone
COMT inhibitor for Parkinson’s disease
Used for
- Used with levodopa and carbidopa to reduce end-of-dose movement symptoms in Parkinson’s disease.
Usual adult dose
200 mg with each levodopa/carbidopa dose, up to 8 times daily; maximum 1,600 mg daily.
Common side effects
- Involuntary movements
- Nausea or diarrhea
- Dizziness
- Brown-orange urine discoloration
Important warnings
- Can worsen involuntary movements; levodopa doses may need adjustment.
- May cause low blood pressure, fainting, or sleepiness.
- Rarely causes severe diarrhea or muscle breakdown.
- Do not stop suddenly without medical supervision.
Pregnancy
Human pregnancy data are limited; use only if potential benefit justifies fetal risk.
Breastfeeding
Effects on a nursing infant and milk production are unknown; use caution.
Interactions
- Nonselective monoamine oxidase inhibitors, such as phenelzine, are contraindicated.
- May increase effects of warfarin; monitoring may be needed.
- Iron supplements can reduce absorption; separate administration by at least 2–3 hours.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.