About ondansetr on hydrochlr
5-HT3 serotonin receptor antagonist
Used for
- Prevention and treatment of nausea and vomiting from chemotherapy or radiotherapy
- Prevention and treatment of nausea and vomiting after surgery
Usual adult dose
Usually 4 mg by injection for postoperative nausea; chemotherapy doses vary by regimen, commonly 8 mg before treatment.
Usual dose in children
For chemotherapy: usually 0.15 mg/kg per dose, up to 8 mg, given before treatment and repeated as prescribed. Postoperative dosing is weight-based.
Common side effects
- Headache
- Constipation or diarrhoea
- Flushing
- Injection-site reactions
Important warnings
- Can prolong the QT heart rhythm; risk is higher with heart problems or low potassium or magnesium.
- Use caution with severe liver disease; maximum daily dose may need restriction.
- Seek urgent care for signs of a severe allergic reaction.
- May mask symptoms of a bowel blockage.
Pregnancy
Use only when clinically needed; pregnancy safety evidence is limited.
Breastfeeding
Breastfeeding safety information is limited; use requires clinical consideration.
Interactions
- Apomorphine: combination is contraindicated because of severe low blood pressure and loss of consciousness.
- Other medicines that prolong QT may increase abnormal heart rhythm risk.
- Serotonergic medicines may rarely increase serotonin syndrome risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.