About ubrogepan t
Calcitonin gene-related peptide receptor antagonist
Used for
- Treats migraine attacks in adults, with or without aura.
Usual adult dose
Take 50 mg or 100 mg once; if needed, repeat after at least 2 hours. Maximum 200 mg in 24 hours.
Common side effects
Important warnings
- Not for preventing migraine or treating cluster headaches.
- Avoid with strong CYP3A4 inhibitors or inducers; these can greatly change ubrogepant levels.
- With moderate CYP3A4 inhibitors or certain other medicines, dose changes or avoiding repeat doses may be needed.
- Severe liver or kidney problems may require dose adjustment or avoidance.
Pregnancy
Human pregnancy information is limited; safety has not been established.
Breastfeeding
It is unknown whether ubrogepant passes into breast milk; effects on a nursing infant are uncertain.
Interactions
- Strong CYP3A4 inhibitors, such as clarithromycin or ketoconazole, can raise levels substantially.
- Strong CYP3A4 inducers, such as rifampin, can reduce effectiveness.
- Verapamil, fluconazole, cyclosporine, and other moderate CYP3A4 inhibitors may require dose adjustment.
- Avoid another ubrogepant dose within 24 hours of certain interacting medicines, including carvedilol or quinidine.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.