About tiopronin
Thiol cystine-binding drug
Used for
- Prevents cystine kidney stones in people with cystinuria when diet and fluids are insufficient.
- Treats severe cystinuria in children and adults.
Usual adult dose
Usually start at 800 mg daily in divided doses; adjust to reduce urinary cystine, often 1,000 mg daily.
Usual dose in children
Usually start at 15 mg/kg daily in divided doses; adjust to reduce urinary cystine.
Common side effects
- Nausea, vomiting, diarrhea, or abdominal discomfort
- Rash, itching, or fever
- Mouth sores or loss of taste
- Reduced blood counts or kidney problems
Important warnings
- Regular urine and blood tests are needed to check treatment effects and detect serious reactions.
- Stop treatment if blood in urine, reduced urine, unusual bruising, or severe rash occurs.
- Use cautiously with kidney disease or a history of blood disorders.
- Maintain high fluid intake and follow a low-sodium diet.
Pregnancy
Use only when clearly needed; discuss risks and benefits with a clinician.
Breastfeeding
It is not known whether tiopronin enters breast milk; weigh treatment benefits against potential infant risk.
Interactions
- Iron supplements may reduce tiopronin absorption; separate doses by at least two hours.
- Other medicines can increase kidney or blood-related risks; provide clinicians with a complete medication list.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.