About isotretinoin usp
Oral retinoid for severe acne
Used for
- Severe acne that has not responded to other treatments.
Usual adult dose
Usually 0.5–1 mg/kg daily in one or two doses, for about 15–20 weeks; dosing is individualized.
Common side effects
- Dry, cracked lips and dry skin
- Dry eyes or nosebleeds
- Muscle or joint aches
- Raised blood fats or liver enzymes
Important warnings
- Can cause severe birth defects; pregnancy prevention and testing are essential.
- Do not donate blood during treatment or for one month afterward.
- Avoid vitamin A supplements and tetracycline antibiotics.
- Mood changes and severe headache or vision problems need prompt assessment.
Pregnancy
Must not be used during pregnancy. Strict pregnancy-prevention measures and testing are required.
Breastfeeding
Avoid during breastfeeding; risk to the infant is uncertain.
Interactions
- Vitamin A supplements may increase toxicity.
- Tetracycline antibiotics may increase risk of raised pressure around the brain.
- Alcohol may worsen effects on liver or blood fats.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.