About indomethacin
Nonsteroidal anti-inflammatory drug (NSAID)
Used for
- Relieves pain and inflammation in arthritis and other joint conditions.
- Treats acute gout attacks.
- Treats painful shoulder inflammation.
Usual adult dose
Usually 50–100 mg rectally at bedtime; dose and duration depend on the condition.
Usual dose in children
For juvenile arthritis, typically 1–2 mg/kg daily in divided doses; specialist supervision is required.
Common side effects
- Nausea, indigestion, or abdominal pain
- Diarrhoea or rectal irritation
- Headache or dizziness
- Fluid retention or raised blood pressure
Important warnings
- Can cause stomach ulcers, bleeding, or perforation.
- May increase risk of heart attack or stroke.
- Avoid with other NSAIDs unless specifically directed.
- Use cautiously with kidney, liver, heart, or bowel problems.
Pregnancy
Avoid from 20 weeks unless a clinician considers it essential; avoid from 30 weeks due to fetal risks.
Breastfeeding
Small amounts may enter breast milk; short-term use is generally considered compatible, but seek professional guidance.
Interactions
- Blood thinners and antiplatelet medicines increase bleeding risk.
- Other NSAIDs or corticosteroids increase stomach and bleeding risks.
- ACE inhibitors, ARBs, and diuretics may affect kidney function.
- Lithium or methotrexate levels may increase.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.