About resmetirom
Thyroid hormone receptor-beta agonist
Used for
- With diet and exercise for adults with noncirrhotic fatty liver disease and moderate-to-advanced liver scarring (MASH with fibrosis).
Usual adult dose
80 mg once daily for adults weighing under 100 kg; 100 mg once daily at or above 100 kg.
Common side effects
- Diarrhea
- Nausea
- Itching
- Abdominal pain
Important warnings
- Not for cirrhosis or severe liver impairment.
- Liver injury has occurred; monitor for symptoms and liver-test changes.
- Gallbladder problems, including gallstones, can occur.
- Use with certain statins may increase statin-related muscle or liver problems.
Pregnancy
Human pregnancy data are limited; potential risks are uncertain.
Breastfeeding
It is unknown whether resmetirom passes into breast milk or affects a nursing infant.
Interactions
- Avoid strong CYP2C8 inhibitors such as gemfibrozil.
- Reduce the dose with moderate CYP2C8 inhibitors such as clopidogrel.
- Resmetirom can raise exposure to several statins; statin dose limits apply.
- Avoid OATP1B1 or OATP1B3 inhibitors such as cyclosporine.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.