About lcz aba sacubitril
Angiotensin receptor-neprilysin inhibitor
Used for
- Heart failure with reduced ejection fraction in adults
- Heart failure in children aged 1 year and older
Usual adult dose
Usually 49/51 mg twice daily, increased after 2–4 weeks to 97/103 mg twice daily as tolerated. A lower starting dose may be used for some patients.
Usual dose in children
Weight-based twice-daily dosing for ages 1 year and older; dose depends on weight and formulation.
Common side effects
- Low blood pressure
- High potassium
- Kidney function changes
- Cough or dizziness
Important warnings
- Do not use with ACE inhibitors or within 36 hours of taking one.
- Avoid with a history of angioedema related to ACE inhibitors or ARBs.
- Monitor blood pressure, kidney function, and potassium.
- Can harm an unborn baby; discontinue if pregnancy occurs.
Pregnancy
Can cause fetal injury or death, especially later in pregnancy; avoid use during pregnancy.
Breastfeeding
Not recommended; information on effects in nursing infants is limited.
Interactions
- ACE inhibitors, including enalapril and lisinopril
- Potassium supplements or potassium-sparing diuretics
- NSAIDs, which may worsen kidney function
- Lithium; sacubitril/valsartan can increase lithium levels
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.