About lopinavir + ritonavir
HIV protease inhibitor combination
Used for
- Treatment of HIV-1 infection, combined with other antiretroviral medicines
Usual adult dose
5 mL by mouth twice daily, with food.
Usual dose in children
Children aged 14 days and older: dose based on weight or body-surface area, twice daily with food; specialist dosing is required.
Common side effects
- Diarrhea, nausea, or vomiting
- Raised blood fats or blood sugar
- Liver enzyme changes
- Taste changes or mouth irritation
Important warnings
- Can cause serious liver problems; risk is higher with existing liver disease.
- May affect heart rhythm or conduction, especially with certain conditions or medicines.
- Contains alcohol and propylene glycol; extra caution is needed in premature or very young infants.
- Do not stop or change treatment without medical supervision.
Pregnancy
Treatment may be used during pregnancy when clinically appropriate; dosing may need adjustment. The oral solution is generally avoided during pregnancy because it contains alcohol and propylene glycol.
Breastfeeding
Breastfeeding is generally not recommended for people with HIV, because HIV can pass to the baby.
Interactions
- Many medicines interact; some combinations can cause serious effects or reduce HIV treatment effectiveness.
- Important interactions include rifampin, St John’s wort, certain heart-rhythm drugs, and some cholesterol medicines.
- Can raise levels of medicines such as sildenafil, midazolam, and certain steroids.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.