About ketoconazole
Oral antifungal; CYP3A4 inhibitor
Used for
- Rarely used for serious fungal infections when safer treatments are unsuitable.
- Sometimes used for certain hormone-related conditions under specialist supervision.
Usual adult dose
Fungal infections: typically 200 mg once daily; specialists may increase to 400 mg daily. Use is restricted.
Common side effects
- Nausea, vomiting, or abdominal pain
- Liver injury, sometimes severe
- Reduced testosterone or adrenal hormone production
- Rash or itching
Important warnings
- Can cause serious, potentially fatal liver damage.
- Many drug interactions can cause dangerous heart rhythms or other harm.
- Restricted use; not recommended for routine fungal infections.
- Seek urgent care for yellow skin, dark urine, severe fatigue, or persistent nausea.
Pregnancy
Avoid unless a specialist determines it is essential; potential fetal harm is a concern.
Breastfeeding
Use only after medical review; safety information is limited.
Interactions
- Do not combine with certain medicines that prolong the QT interval.
- Strong enzyme-inducing drugs, such as rifampin, can greatly reduce ketoconazole levels.
- Ketoconazole can raise levels of many medicines, including some statins and sedatives.
- Acid-reducing medicines can lower absorption.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.