About mitoxantrone hydrochloride
Antineoplastic anthracenedione
Used for
- Certain cancers, including acute myeloid leukemia and advanced prostate cancer.
- Relapsing forms of multiple sclerosis in selected cases.
Usual adult dose
Cancer doses vary by regimen and body surface area. Multiple sclerosis: 12 mg/m² intravenously every three months, with strict lifetime dose limits.
Common side effects
- Low blood cell counts and increased infection risk
- Nausea, vomiting, diarrhea, or mouth sores
- Hair loss and fatigue
- Heart damage or abnormal heart rhythms
Important warnings
- Can cause severe bone marrow suppression and serious infections.
- May cause heart failure; heart function requires monitoring before and during treatment.
- May cause treatment-related leukemia; lifetime exposure is limited.
- Urine and other body fluids may turn blue-green temporarily.
Pregnancy
May harm an unborn baby. Avoid during pregnancy; effective contraception is needed during treatment and for the period specified by the treating specialist.
Breastfeeding
Breastfeeding is not recommended during treatment because of potential serious harm to the infant.
Interactions
- Other medicines that suppress bone marrow can increase infection and bleeding risks.
- Other heart-damaging medicines or chest radiation may increase cardiac injury.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.