About ate ever olimu s
mTOR kinase inhibitor
Used for
- Treats advanced kidney cancer, breast cancer, pancreatic neuroendocrine tumors, and certain other cancers.
- Treats tuberous sclerosis complex-related seizures and noncancerous tumors.
Usual adult dose
Usually 10 mg once daily for cancer; dosing varies by condition and other medicines.
Usual dose in children
For tuberous sclerosis complex, dose is based on body surface area and condition; specialist dosing is required.
Common side effects
- Mouth sores
- Infections
- Rash
- Diarrhea or fatigue
Important warnings
- Can cause serious infections and lung inflammation.
- May impair wound healing; surgery may require treatment interruption.
- Can raise blood sugar, cholesterol, and triglycerides.
- Avoid live vaccines; monitor blood counts and kidney and liver function.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 8 weeks after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment and for 2 weeks after the last dose.
Interactions
- Strong CYP3A4/P-glycoprotein inhibitors can increase everolimus levels.
- Strong CYP3A4/P-glycoprotein inducers can reduce everolimus levels.
- Avoid grapefruit and grapefruit juice.
- Everolimus can reduce the effectiveness of some vaccines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.