About elacestra nt
Selective estrogen receptor degrader
Used for
- Treats estrogen receptor-positive, HER2-negative advanced breast cancer with an ESR1 mutation after cancer progression on hormone therapy.
Usual adult dose
345 mg by mouth once daily with food, until cancer progresses or side effects become unacceptable.
Common side effects
- Nausea
- High cholesterol or triglycerides
- Muscle or joint pain
- Fatigue or reduced appetite
Important warnings
- Can increase cholesterol and triglycerides; blood tests are needed during treatment.
- May cause fetal harm; effective contraception is required during treatment and for one week afterward.
- May reduce fertility; discuss fertility preservation before treatment.
- Liver problems may require monitoring or dose changes.
Pregnancy
May harm an unborn baby. Not recommended during pregnancy; avoid pregnancy during treatment and for one week afterward.
Breastfeeding
Do not breastfeed during treatment and for one week after the last dose.
Interactions
- Strong or moderate CYP3A4 inhibitors can increase drug levels and side effects.
- Strong or moderate CYP3A4 inducers can lower drug levels and effectiveness.
- Avoid grapefruit and grapefruit juice, which can increase drug levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.