About phentolamine mesilate
Nonselective alpha-adrenergic blocker
Used for
- Reverses certain effects of injected local anesthetics containing epinephrine
- Treats high blood pressure from catecholamine-producing tumors or related procedures
- Prevents or treats tissue injury from accidental norepinephrine leakage
Usual adult dose
Varies by use: commonly 5 mg by injection for local anesthetic reversal; other uses require monitored, individualized dosing.
Usual dose in children
Specialist-directed dosing varies by indication; not routinely used in children.
Common side effects
- Low blood pressure, dizziness, or fainting
- Fast heartbeat or abnormal heart rhythm
- Nasal congestion
- Nausea or vomiting
Important warnings
- May cause a sudden drop in blood pressure or rapid heartbeat.
- Use caution with coronary artery disease or other heart conditions.
- Intravenous use requires blood-pressure and heart-rate monitoring.
- Injection-site leakage can cause tissue injury.
Pregnancy
Human pregnancy information is limited; use only when the expected benefit justifies potential risk.
Breastfeeding
Information is limited; whether phentolamine enters breast milk is not well established.
Interactions
- Other blood-pressure-lowering medicines may increase low blood pressure.
- Epinephrine or norepinephrine effects may be altered.
- Drugs that affect heart rhythm may increase cardiac risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.